Giovanni Simeone's textbook opening goal and a Joao Pedro late effort helped Cagliari beat 3-1 visiting Genoa, who scored an own goal in the Italian Serie A.
The son of Atletico Madrid's coach Diego Simeone connected with a cross from Artur Ionita one minute into the second half on Friday night.
Christian Kouame moved his tally three goals this season when he levelled with a clinical drive in the 83rd, but Zapata deflected into his own goal two minutes later and Joao Pedro struck for 3-1 on a counter-attack on 87.
The Sardinia side moved on to six points as Genoa stayed on four.
AC Milan and Inter Milan meet Saturday in a city derby that highlights round four.