The toll has continued to rise after the latest ceasefire took effect on October 10.
Israel still carries out strikes in response to what it has called violations of the truce and bodies from earlier in the war are being recovered from the rubble.
Gaza's Health Ministry says the Palestinian toll is now 70,100.
The ministry operates under the Hamas-run government. It is staffed by medical professionals and maintains detailed records viewed as generally reliable by the international community.
Staff at Nasser Hospital, which received the bodies of the two children in southern Gaza, said the brothers, ages eight and 11, died when an Israeli drone struck close to a school sheltering displaced people in the town of Beni Suhaila.
Israel's military said it killed two people who crossed into an Israeli-controlled area, "conducted suspicious activities" and approached troops.
The statement didn't mention children. The military said it also killed another person in a separate but similar incident in the south.
At least 352 Palestinians have been killed across the territory since the ceasefire between Israel and Hamas took effect on October 10, according to Gaza's Health Ministry, which doesn't differentiate between civilians and combatants.
Israel says its strikes are aimed at militants violating the truce. Both Israel and Hamas have accused the other of violating the deal. Hamas again urged mediators on Saturday to pressure Israel to stop what it called ceasefire violations in Gaza.
A US blueprint outlining the future of Gaza, which has been devastated by more than two years of war, is still in the early stages.
The plan to secure and govern the territory authorises an international stabilisation force to provide security, approves a transitional authority to be overseen by US President Donald Trump and envisions a possible future path to an independent Palestinian state.
The war began with the Hamas-led attack on southern Israel on October 7, 2023, in which around 1200 people were killed and more than 250 others were taken hostage. Almost all of the hostages or their remains have been returned in ceasefires or other deals.
The remains of two hostages, one Israeli and a Thai national, are still to be returned. Israelis rallied again Saturday night in Tel Aviv for their return.
Elsewhere in the region Israeli forces have pushed forward on a number of other fronts in the region in recent weeks.
Syrian officials said that Israeli forces raided a Syrian village on Friday and opened fire when they were confronted by residents, killing at least 13 people.
Israel said it conducted the operation to apprehend suspects of a militant group planning attacks in Israel, and that the militants opened fired at troops, wounding six.
Israel also has escalated strikes in Lebanon, saying it's targeting Hezbollah sites and asserting that the militant group is attempting to rearm.
