The Grammy winning singer, 30, teased the release of the track Yes, And? last weekend by sharing the title alongside a blurred photo of her face to Instagram.
It follows after her chart-topping 2020 album Positions, which also had a deluxe edition released the following year with an additional song called Test Drive.
The song is expected to feature on her forthcoming seventh album.
The house-inspired track opens with a repetitive, catchy beat that builds before her soprano vocals chime in.
The song appears to address people having opinions on her life and the instrumental channels Madonna's 1990 hit Vogue.
She responds to the comments in the chorus by singing: "Say that s*** with your chest, keep moving like 'What's next?' 'Yes, and?'"
It is brimming with her signature high vocal trills, which is sure to please her fan base.
Recorded in New York City, the new single was written and produced by Grande alongside Max Martin and Ilya Salmanzadeh.
A teaser for the music video, which was set to be released at 3pm local time on Friday, sees someone holding a red card which says "ag7" with coordinates listed underneath it and "your presence has been exclusively requested" inscribed on the back.
Seven of the US singer's tracks have gone to number one in the UK singles chart including 2014 hit Problem featuring Iggy Azalea and 2018 song Thank U Next.
Grande's other hit records include 2016's Dangerous Woman and 2019's 7 Rings, which both went to number one as well.
The singer started as an actress on American children's TV channel Nickelodeon, portraying Cat Valentine on Victorious, before she went on to star in a spin-off show called Sam And Cat.
Her debut album Yours Truly was released in 2013 and peaked in the UK charts at number seven.
The pop superstar is also starring as Glinda in the upcoming film adaptation of Wicked, the musical that tells the backstory of The Wizard Of Oz.
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