Lowry's tee shot on the eighth hole pitched in the fairway and bounced sideways into a pitch mark left by another player.
That meant the former Open champion was not allowed relief for an embedded ball and, after confirming the situation with a rules official, Lowry could only hit his second shot into a greenside bunker.
Lowry responded by slamming his club into the turf and exclaiming loudly "F*** this place" before going on to make a bogey five and flipping his middle finger at the hole as he tapped in.
The dropped shot contributed to a second round of 71, meaning Lowry missed the cut by a single shot on two over par.
"You hit a lovely tee shot, you're not expecting that," Lowry said of the eighth hole.
"I was obviously very annoyed with that because I felt like I had quite a bit of momentum going in the round and standing there with 40 or 50 yards to the pin off the fairway it's an easy pitch shot for me and I walk away making bogey.
"You don't get many chances and I feel like the eighth hole is one, and when you don't take advantage of a good tee shot or you get a bit of a break like that it's not ideal is it?"
Lowry was particularly unhappy with the unsolicited input of an on-course reporter, adding: "The ESPN guy was a bit too involved when he wasn't asked to be and that's what annoyed me a lot.
"He came straight over and said 'That's not your pitch mark' and like that's not for you to talk about, it's for me to call a rules official and decide what happens.
"I wasn't arguing that it was my pitch mark, I was trying to be 100 per cent sure because imagine if I come in (after the round) and all of a sudden somebody told me that was my pitch mark.
"They told Brooks (Koepka) his ball was okay yesterday and it was on the driving range so you need to be careful about what you're doing because there's so much at stake."
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