It is the fifth straight time West Indies have been sent in after Australia captain Mitchell Marsh won the toss on Monday (Tuesday AEST).
Paceman Ben Dwarshuis and game-three century-maker Tim David have been recalled in place of quick Xavier Bartlett and batter Cooper Connolly for the match in Basseterre, St Kitts.
West Indies have also made two changes, with quick Alzarri Joseph and batter Keacy Carty coming in for Roston Chase and the injured Rovman Powell.
Australia have won the four previous T20 games after taking out all three Tests against West Indies.
Legspinner Adam Zampa is playing his 100th T20I, just the fourth Australian to reach that milestone.
Australia have won 11 of their past 12 T20I matches, while West Indies have suffered 10 losses from their past 11 games.
WEST INDIES: Brandon King, Shai Hope (capt), Keacy Carty, Shimron Hetmyer, Sherfane Rutherford, Romario Shepherd, Jason Holder, Matthew Forde, Akeal Hosein, Alzarri Joseph, Jediah Blades
AUSTRALIA: Glenn Maxwell, Mitchell Marsh (capt), Josh Inglis, Cameron Green, Tim David, Mitchell Owen, Aaron Hardie, Ben Dwarshuis, Sean Abbott, Nathan Ellis, Adam Zampa
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