Captain Mitch Marsh opted to give his revamped batting line-up a run chase at Sabina Park in Kingston.
Power hitter Mitch Owen will make his Australian debut batting in the middle order in the first game of the five-match series.
The Australians have also summoned Jake Fraser-McGurk to open the innings after the 23-year-old was initially overlooked for the tour.
Fraser-McGurk was called up when paceman Spencer Johnson (back) was ruled out.
Now, a side strain to incumbent opener Matt Short, who is returning home, has gifted opportunity to Fraser-McGurk, who averages 16.14 from seven T20 internationals.
Australia's regular middle-order blaster Tim David has been rested for the fixture while recovering from a hamstring strain sustained in the IPL, with Cooper Connolly to bat at seven.
Teams:
Australia: Mitch Marsh (capt), Jake Fraser-McGurk, Josh Inglis, Cameron Green, Glenn Maxwell, Mitch Owen, Cooper Connolly, Ben Dwarshuis, Sean Abbott, Nathan Ellis, Adam Zampa.
West Indies: Shai Hope (capt), Roston Chase, Shimron Hetmyer, Jason Holder, Akeal Hosein, Alzarri Joseph, Brandon King, Gudakesh Motie, Rovman Powell, Andre Russell, Sherfane Rutherford.
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