The Hurricanes' bowlers were outstanding on a traditionally good batting wicket at the Junction Oval in Melbourne on Sunday.
Heather Graham (3-12), Molly Strano (3-14) and Nicola Carey (3-24) limited the Renegades to just 9-101 after the Hurricanes won the toss and elected to field.
Only West Indies superstar Hayley Matthews got going for the Renegades, hitting 39 as wicketkeeper Josephine Dooley (16) was the only other batter to reach double figures.
The Hurricanes had little trouble during the chase, reaching the target with 14 balls to spare.
Opener Elyse Villani continued her fine tournament with an unbeaten 46, while Carey blasted 25no to cap off a handy all-round performance.
Hobart moved up to fifth in the win, one point clear of the Sydney Sixers, with two games left.
The Renegades remain on the bottom of the table, with just two victories.
In Sunday's other game, the Melbourne Stars will face the Brisbane Heat without captain Meg Lanning.
The former Australian captain, who recently retired from international cricket, withdrew from the match only hours before the toss.
Young allrounder Annabel Sutherland will captain the Stars in Lanning's absence.
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