And the club has gone to extreme measures to make sure the Panthers players feel comfortable in what was previous enemy territory for the next two years, as their new stadium is built.
On the last day of their pre-season camp, players were dropped in the middle of the surrounding Parramatta Park and told CommBank Stadium was their final destination.
They were ordered to complete a boxing course, complete a 10km run and lug their gear to their new home.
There, they also took part in a smoking ceremony on Burramattagal land and were reminded of the importance of the place and welcomed.
Players then visited their new sheds before walking barefoot on the field, finding a piece of grass and visualising playing there.
The Panthers are hoping to make it the ultimate house-warming when they host the Sydney Roosters on Friday night.
"We understand that's our home now for the next two seasons," Penrith captain Isaah Yeo told AAP.
"And it's important to get familiarised with everything and understand there's going to be a lot of hard work put in at that stadium.
"In the long run, it's going to be all worth it because we've got a brand new stadium in Penrith."
For all the talk of Jarome Luai and Nathan Cleary, or James Fisher-Harris and Moses Leota, the other bond broken this season is the Panthers and Penrith Park.
Through Penrith's five years of dominance, they have lost only seven times at the ground.
When they were anywhere near full strength with Cleary and Luai in the halves, the record stood at 32-4.
"We had a pretty good record out at BlueBet and we love playing there, but we've got a pretty good record at other places as well," Penrith coach Ivan Cleary said.
"It started back in 2021 when we were up in Queensland (through COVID) and we played at Suncorp most weeks.
"We ended up having some success up there too, so it's just another field."
A crowd of around 15,000 is expected on Friday night, which would be lower than any attendance figure at Penrith Park since COVID-19 lockdowns lifted.
But it is not lost on Penrith that the move 35km east can be a way of making 2025 feel different, as has been a key in each season of their illustrious four-peat.
"It can certainly help," Yeo said.
"I don't think this is a hardship. But it might not be so lopsided Penrith's way in terms of fans and crowd and noise.
"Any time you can be a part of environments where it might not be like it is at home. I think it'll be a good thing in the long run."
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