Sinner will go for revenge against Carlos Alcaraz in Sunday's final after ruthlessly ending an ailing Djokovic's title dreams.
It had seemed like Centre Court, where he has lifted the trophy seven times, would be Djokovic's best hope of one final blow for the old guard against the remarkable new kings of tennis.
But Sinner took just an hour and 55 minutes on Friday to squash that theory flat, with Djokovic taking a medical timeout for treatment to his left thigh after the second set of a 6-3 6-3 6-4 defeat.
Djokovic has reached the semi-finals at each of the grand slams this year but has not made a final, while this is the second time he has been physically compromised after he retired injured at the Australian Open.
The 38-year-old, who suffered a nasty fall late in his quarter-final, said: "It wasn't really a pleasant feeling on the court. I don't want to talk in details about my injury and just whine about not managing to play my best.
"I want to congratulate Jannik for another great performance. That's it. He's in the finals. He was too strong. I do feel disappointed that I just wasn't able to move as well as I thought or hoped that I would.
"I don't think it's bad fortune. It's just age, the wear and tear of the body. As much as I'm taking care of it, the reality hits me right now, last year and a half, like never before, to be honest.
"It's tough for me to accept that because I feel like, when I'm fresh, when I'm fit, I can still play really good tennis. I've proven that this year. But I guess playing best-of-five, particularly this year, has been a real struggle for me physically.
"The longer the tournament goes, the worse the condition gets. I reach the final stages, I reach the semis of every slam this year, but I have to play Sinner or Alcaraz.
"These guys are fit, young, sharp. I feel like I'm going into the match with the tank half-empty. It's just not possible to win a match like that."
Djokovic gave a wave to all sides of Centre Court as he walked off, but he hopes his final act on one of his most successful stages can be something more uplifting.
"I would be sad, but hopefully it's not my last match on the Centre Court," he said. "I'm not planning to finish my Wimbledon career today. So I'm planning to come back definitely at least one more time."
13°C