Sergeant Paul Nicoll said investigations were continuing into the most serious accident in Sturt St last week.
The 56-year-old male driver was flown to The Alfred hospital where he remains in a serious condition with several fractures in his skull and spinal cord skull.
Police believe alcohol and speed may be factors in the crash.
During the school holidays, more than 500 random breath tests and several oral fluid tests were done, netting two drunk drivers and four drug drivers.
“While these detection rates are on the low end of the scale, we can only remain truly satisfied when there are no drink or drug drivers detected,” Sgt Nicoll said.
Echuca police were also called to a collision on Wednesday on the corner of the Northern Hwy and Rose St.
Over the Deni Ute Muster weekend, 2701 random breath tests were done across the Murray River Police District.
Inspector Paul Huggett said 184 infringement notices were issued.
“Disappointingly, 125 of them were for speeding,” he said.
“No local drunk drivers were detected.
“The weekend caused no significant issues other than the usual traffic congestion exasperated by the roadworks undertaken around the Echuca CBD at the moment.”