Keir Starmer declined to comment directly about King Charles III's disgraced younger brother, but told reporters traveling with him for the Group of 20 summit in Johannesburg that as a "general principle" people should provide evidence to investigators.
"I don't comment on his particular case,'' Starmer said.
"But as a general principle I've held for a very long time is that anybody who has got relevant information in relation to these kind of cases should give that evidence to those that need it.''
The former prince, now known as Andrew Mountbatten-Windsor, has so far ignored a request from members of the House Oversight Committee for a "transcribed interview" about his "long-standing friendship" with Epstein.
Andrew was stripped of his royal titles and honours last month as the royal family tried to insulate itself from criticism about his relationship with Epstein.
Starmer's comments came after Robert Garcia of California, the committee's ranking Democrat, and Suhas Subramanyam, a Democrat from Virginia, said Andrew "continues to hide" from serious questions.
"Our work will move forward with or without him, and we will hold anyone who was involved in these crimes accountable, no matter their wealth, status or political party," they said in a statement released on Friday.
"We will get justice for the survivors."
