Speaking on Thursday at a legislative hearing at the National Capitol to denounce US sanctions on Cuban oil imports, Josefina Vidal accused Washington of fabricating pretexts to portray Cuba as a threat to US national security to justify aggression.
"Every day the danger of military aggression against Cuba grows," she said.
Under President Donald Trump, the US has effectively imposed a blockade on Cuba by threatening sanctions on countries supplying it with fuel, triggering power outages and exacerbating its worst crisis in decades.
US Secretary of State Marco Rubio on Wednesday said he was confident dialogue between the nations, which began around March, would have "a good result".
Cuban authorities have said they will not allow interference in internal affairs and have criticised the US for a lack of good faith.
"A channel of exchange between the two governments remains open, but there has not been much progress. We have reason to doubt the seriousness and responsibility of the United States government," Vidal said.
In the latest escalation in Trump's pressure campaign against Cuba's Communist government, the US formally charged former president Raul Castro with four counts of murder for the 1996 downing of civilian aircraft operated by Miami-based exiles.
Foreign Minister Bruno Rodriguez has warned that any military action would lead to a "bloodbath" in which thousands of Cubans and Americans would die.
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