The comedian, actor and podcaster, 51, is accused by six women of sexual abuse allegations spanning 10 years from 1999 to 2009.
He denies all the charges: three counts of rape, three charges of sexual assault, and one allegation of indecent assault.
Brand arrived at Southwark Crown Court in a black Mercedes on Tuesday for the first of two days of pre-trial hearings.
Wearing a grey suit jacket and sunglasses, Brand was flanked by a security guard and accompanied by a woman as he walked slowly walked past waiting news photographers.
He stayed silent on his entry to court, for the start of two days of legal argument scheduled to take place on Tuesday and Wednesday.
His trial begins on Monday, October 12, with the case expected to last up to 10 weeks.
Previous hearings have heard Brand, who denies all the allegations of non-consensual sexual activity, is accused of raping a woman in a hotel room at the Labour Party conference in Bournemouth, grabbing a TV worker's breasts and forcing her into a sex act in a toilet and kissing and groping a radio station worker.
Brand became one of Britain's best-known stand-up comedians in the 2000s, presented spin-off shows for TV's Big Brother and starred in a series of Hollywood films.
In recent years, he has pivoted to podcasting and online influencing, and now lives in the United States.
Brand is on bail during criminal proceedings.
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